![]() The new FDA Opioid Analgesic REMS is a designed to assist in communicating the serious risks of opioid pain medications to patients and health care professionals. The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for all opioids intended for outpatient use. Do not abruptly discontinue in the physically dependent patient.Monitor for signs and symptoms of withdrawal if they occur, raise the dose to the previous level and taper more slowly.Taper dose gradually, by 25% to 50% every 2 to 4 days. ![]() Concomitant use of CYP450 3A4 inducers or inhibitors may require dose adjustment: Consult drug interactionsĭiscontinuation of Therapy in the Physically Dependent Patient:.Consider decreasing dose of concomitant CNS depressant drug monitor for signs of respiratory depression, sedation, and hypotension.Initial dose: Oxycodone 7.5 mg/Acetaminophen 325 mg ER: 1 tablet orally every 12 hours adjust dose as needed.To avoid overdose of acetaminophen, it is best to use just 1 acetaminophen product at a time.Take into account all acetaminophen products when calculating daily dose.Maximum Acetaminophen Dose is 4 g in 24 hours Initial dose: Oxycodone 7.5 mg/Acetaminophen 325 mg ER: 1 tablet orally every 12 hours adjust dose as needed Dose AdjustmentsĮlderly, Cachectic, or Debilitated Patients: Use with caution generally starting at the low end of the dosing range, titrate dose slowly while monitoring closely for signs of CNS or respiratory depression. Initial dose: Oxycodone 7.5 mg/Acetaminophen 325 mg ER: 1 tablet orally every 12 hours adjust does as needed Liver Dose Adjustments Use with caution therapy should be initiated with a lower than usual dose titrate carefully.Use: For the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Oxycodone/acetaminophen ER Tablets are not interchangeable with other oxycodone/acetaminophen products.Monitor patients closely for respiratory depression within the first 24 to 72 hours of initiating therapy and following any increase in dose.Because of the risks of addiction, abuse and misuse, the lowest effective dose for the shortest duration consistent with individual patient treatment goals should be used.Doses should be individually titrated to provide adequate analgesia while minimizing adverse reactions.The second dose may be administered as early as 8 hours after initial dose if needed however, subsequent doses should be administered every 12 hours.Verify dose in mg and mL prior to administrationĪs First Opioid Analgesic: 2 tablets orally every 12 hours (each ER tablet contains oxycodone 7.5 mg/acetaminophen 325 mg).Maximum dose: Oxycodone 60 mg/acetaminophen 3900 mg (60 mL) in 24 hours Usual dose: Oxycodone 5 mg/acetaminophen 325 mg (5 mL) orally every 6 hours as needed for pain Oral Solution: Oxycodone 5 mg/acetaminophen 325 mg per 5 mL: Oxycodone 10 mg/acetaminophen 300 or 325 mg: 1 tablet orally every 6 hours as needed for pain Oxycodone 7.5 mg/acetaminophen 300 or 325 mg: 1 tablet orally every 6 hours as needed for pain Oxycodone 5 mg/acetaminophen 300 or 325 mg: 1 tablet orally every 6 hours as needed for pain Lowery was being held without bond Monday.Oxycodone 2.5 mg/acetaminophen 300 or 325 mg: 1 to 2 tablets every 6 hours She was charged with violating the public oath of office, giving inmates gun, drugs or alcohol, criminal attempt, and crossing a guard line with guns, drugs or alcohol, jail records show. In Sunday’s arrest, no details were released on what Lowery was attempting to smuggle into inmates. She has been charged with being a party to a crime and obstructing or hindering law enforcement officers.Ĭorrectional Officer Sean Hollinshead, according to Allen, was taken into custody in May for his alleged role in a “vicious attack” on an inmate and charged with criminal negligence and violation of his oath of office.Īlso in May, Officer Tabitha Clifton and nurse Jessica Castellanos were arrested after they were accused of giving inmates prohibited items, the sheriff said. ![]() A day later, the sheriff said a fellow contractor, Sarai Ali, was arrested for allegedly aiding wanted people, sharing confidential information and encouraging people to steal from inmates. A contractor, Iyana Dixon, was charged with financial transaction card fraud and theft and accused of stealing an inmate’s credit card and using it at a Macy’s.
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